肌腱
组织工程
再生(生物学)
体内
基质(化学分析)
体外
生物医学工程
细胞外基质
细胞生物学
医学
生物
解剖
化学
生物技术
生物化学
色谱法
作者
Pierre Bagnaninchi,Ying Yang,Alicia J. El Haj,Nicola Maffulli
标识
DOI:10.1136/bjsm.2006.030643
摘要
Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.
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