哌拉西林
哌拉西林/他唑巴坦
他唑巴坦
渗透(战争)
药代动力学
医学
抗菌剂
化学
药理学
微生物学
抗生素
细菌
生物
工程类
铜绿假单胞菌
运筹学
遗传学
作者
William O’Brien,Shelley George
标识
DOI:10.1155/s1064744994000347
摘要
This study was undertaken to determine plasma and pelvic tissue concentrations of piperacillin/tazobactam following a single intravenous administration.Plasma and tissue samples were obtained following administration of 3 g of piperacillin and 0.375 g of tazobactam. Concentrations of these agents were determined by chromatography.Plasma concentrations (mean +/-SD) for piperacillin/tazobactam were 208 +/- 87/27 +/- 8 and 95 +/- 53/14 +/- 2, respectively, at 30 and 60 min after the start of the infusion. The 8:1 ratio between piperacillin and tazobactam in plasma remained constant for up to 96 min. Tissue concentrations yielded a broader range, but each agent achieved significant penetration in each of the tissues studied.Piperacillin/tazobactam demonstrates favorable penetration in female genital tract tissues and Should be considered a potentially effective agent for female pelvic infections.
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