Tumor Subtype-Specific Cancer–Testis Antigens as Potential Biomarkers and Immunotherapeutic Targets for Cancers

免疫疗法 肺癌 癌症研究 癌症 癌症免疫疗法 黑色素瘤 抗原 DNA甲基化 生物 医学 肿瘤科 基因表达 免疫学 基因 内科学 遗传学
作者
Jun Yao,Otávia L. Caballero,W.K. Alfred Yung,John N. Weinstein,Gregory J. Riggins,Robert L. Strausberg,Qi Zhao
出处
期刊:Cancer immunology research [American Association for Cancer Research]
卷期号:2 (4): 371-379 被引量:96
标识
DOI:10.1158/2326-6066.cir-13-0088
摘要

Cancer-testis (CT) antigens are potential targets for cancer immunotherapy because of their restricted expression in immune-privileged germ cells and various malignancies. Current application of CT-based immunotherapy has been focused on CT expression-rich tumors such as melanoma and lung cancers. In this study, we surveyed CT expression using The Cancer Genome Atlas (TCGA) datasets for ten common cancer types. We show that CT expression is specific and enriched within certain cancer molecular subtypes. For example, HORMAD1, CXorf61, ACTL8, and PRAME are highly enriched in the basal subtype of breast cancer; MAGE and CSAG are most frequently activated in the magnoid subtype of lung adenocarcinoma; and PRAME is highly upregulated in the ccB subtype of clear cell renal cell carcinoma. Analysis of CT gene expression and DNA methylation indicates that some CTs are regulated epigenetically, whereas others are controlled primarily by tissue- and subtype-specific transcription factors. Our results suggest that although for some CT expression is associated with patient outcome, not many are independent prognostic markers. Thus, CTs with shared expression pattern are heterogeneous molecules with distinct activation modes and functional properties in different cancers and cancer subtypes. These data suggest a cancer subtype-orientated application of CT antigen as biomarkers and immunotherapeutic targets.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
FantasyGud发布了新的文献求助10
1秒前
11655165发布了新的文献求助10
2秒前
3秒前
4秒前
gxm1234567发布了新的文献求助10
4秒前
shi完成签到,获得积分10
4秒前
4秒前
共享精神应助明亮映阳采纳,获得10
6秒前
乐观梦芝发布了新的文献求助10
7秒前
刻苦的白梅完成签到,获得积分20
7秒前
阿航发布了新的文献求助10
8秒前
脑洞疼应助su采纳,获得10
9秒前
10秒前
10秒前
junsizzz发布了新的文献求助10
10秒前
zxf完成签到,获得积分20
10秒前
Orange应助wwwww采纳,获得10
11秒前
11秒前
12秒前
13秒前
Transient发布了新的文献求助10
14秒前
SUN完成签到,获得积分10
14秒前
科研通AI2S应助科研通管家采纳,获得10
15秒前
15秒前
ferrycake应助科研通管家采纳,获得20
15秒前
16秒前
共享精神应助科研通管家采纳,获得10
16秒前
JamesPei应助科研通管家采纳,获得10
16秒前
16秒前
Leif应助科研通管家采纳,获得20
16秒前
CodeCraft应助科研通管家采纳,获得10
16秒前
cocolu应助科研通管家采纳,获得10
16秒前
cocolu应助科研通管家采纳,获得10
16秒前
pluto应助科研通管家采纳,获得30
16秒前
萧水白应助科研通管家采纳,获得10
16秒前
共享精神应助科研通管家采纳,获得10
16秒前
丘比特应助科研通管家采纳,获得10
17秒前
爆米花应助科研通管家采纳,获得10
17秒前
ferrycake应助科研通管家采纳,获得20
17秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Effect of reactor temperature on FCC yield 2000
Introduction to Spectroscopic Ellipsometry of Thin Film Materials Instrumentation, Data Analysis, and Applications 1800
Natural History of Mantodea 螳螂的自然史 1000
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
How Maoism Was Made: Reconstructing China, 1949-1965 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3313969
求助须知:如何正确求助?哪些是违规求助? 2946329
关于积分的说明 8529696
捐赠科研通 2621983
什么是DOI,文献DOI怎么找? 1434250
科研通“疑难数据库(出版商)”最低求助积分说明 665190
邀请新用户注册赠送积分活动 650774