Hemoglobin Broussais: α90 Lys → Asn

A hemoglobin with the electrophoretic properties of hemoglobin K or J was found in three generations of a Canadian family in Saskatoon. By analysis of the tryptic peptides of the whole globin and of the isolated abnormal α chains, it was characterized as α 90 Lys → Asn (hemoglobin Broussais). This is the second report of the occurrence of this hemoglobin variant.