化学
亲脂性
酰胺
产量（工程）
组合化学
试剂
胺气处理
结合
相（物质）
有机化学
数学
数学分析
冶金
材料科学
作者
Jeffrey G. Aaronson,Lee J. Klein,Aaron Momose,Ann O’Brien,Anthony W. Shaw,Thomas J. Tucker,Yu Yuan,David M. Tellers
摘要
Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.
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