God gives IL-19 with both hands: Anti-inflammatory but pro-angiogenic

Peripheral artery diseases (PAD) and coronary artery diseases (CAD) are caused by atherosclerosis and thrombosis. As a complication of PAD, critical limb ischemia (CLI) causes non-healing ulcers and pain on walking. Patients with CLI are generally treated with a combination of risk factor modifiers, such as statins, anti-platelet drugs, and angioplasty. These treatments, however, occasionally do not restore blood flow to a degree that allows for normal tissue function [1]. Therapeutic angiogenesis offers a promising approach to promoting new vessel growth and re-establishing sufficient blood flow in the limb.