格尔德
医学
肥胖
食管
疾病
食管炎
回流
内科学
胃肠病学
巴雷特食管
风险因素
人口
减肥
腺癌
癌症
环境卫生
作者
Girish Anand,Philip O. Katz
标识
DOI:10.1016/j.gtc.2009.12.002
摘要
Gastroesophageal reflux disease (GERD) is a common condition, with multifactorial pathogenesis, affecting up to 40% of the population. Obesity is also common. Obesity and GERD are clearly related, both from a prevalence and causality association. GERD symptoms increase in severity when people gain weight. Obese patients tend to have more severe erosive esophagitis and obesity is a risk factor for the development of Barrett's esophagus and adenocarcinoma of the esophagus. Patients report improvement in GERD when they lose weight and there are several reports suggesting a decrease in GERD symptoms after bariatric surgery. At present, there is little evidence that obesity has any effect on the efficacy of antisecretory therapy, with conflicting data on surgical outcomes. This review attempts to put in perspective the relationship of these two common entities.
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