Advances in brain drug targeting and delivery: limitations and challenges of solid lipid nanoparticles

固体脂质纳米粒 药物输送 专家意见 药品 纳米技术 医学 靶向给药 药理学 重症监护医学 材料科学
作者
Medha Patel,Eliana B. Souto,Kamalinder K. Singh
出处
期刊:Expert Opinion on Drug Delivery [Informa]
卷期号:10 (7): 889-905 被引量:103
标识
DOI:10.1517/17425247.2013.784742
摘要

Introduction: With the advancement in the field of medical colloids and interfacial sciences, the life expectancy has been greatly improved. In addition, changes in the human lifestyle resulted in development of various organic and functional disorders. Central nervous system (CNS) disorders are most prevalent and increasing among population worldwide. The neurological disorders are multi-systemic and difficult to treat as portal entry to brain is restricted on account of its anatomical and physiological barrier. Areas covered: The present review discusses the limitations to CNS drug delivery, and the various approaches to bypass the blood brain barrier (BBB), focusing on the potential use of solid lipid nanoparticles (SLN) for drug targeting to brain. The methods currently in use for SLN production, physicochemical characterization and critical issues related to the formulation development suitable for targeting brain are also discussed. Expert opinion: The potential advantages of the use of SLN over polymeric nanoparticles are due to their lower cytotoxicity, higher drug loading capacity and scalability. In addition, their production is cost effective and the systems provide a drug release in a controlled manner up to several weeks. Drug targeting potential of SLN can be enhanced by attaching ligands to their surface.
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