瑞士/瑞士法郎
生物
遗传学
基因
染色质
酿酒酵母
抄写(语言学)
SMARCA4型
转录因子
染色质结构重塑复合物
组蛋白
染色质重塑
语言学
哲学
作者
Fred Winston,Marian Carlson
标识
DOI:10.1016/0168-9525(92)90300-s
摘要
Genetic studies of many diversely regulated genes in the yeast Saccharomyces cerevisiae have identified two groups of genes with global functions in transcription. The first group comprises five SNF and SWI genes required for transcriptional activation. The other group, containing SPT and SIN genes, was identified by suppressor analysis and includes genes that encode histones. Recent evidence suggests that these SNF/SWI and SPT/SIN genes control transcription via effects on chromatin. SNF2/SWI2 sequence homologues have been identified in many organisms, suggesting that the SNF/SWI and SPT/SIN functions are conserved throughout eukaryotes.
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