基因组
生物
环境DNA
基因组
数据科学
生态学
计算生物学
计算机科学
生物多样性
遗传学
基因
作者
Jack A. Gilbert,Christopher L. Dupont
出处
期刊:Annual Review of Marine Science
[Annual Reviews]
日期:2011-01-15
卷期号:3 (1): 347-371
被引量:378
标识
DOI:10.1146/annurev-marine-120709-142811
摘要
Metagenomics literally means “beyond the genome.” Marine microbial metagenomic databases presently comprise ∼400 billion base pairs of DNA, only ∼3% of that found in 1 ml of seawater. Very soon a trillion-base-pair sequence run will be feasible, so it is time to reflect on what we have learned from metagenomics. We review the impact of metagenomics on our understanding of marine microbial communities. We consider the studies facilitated by data generated through the Global Ocean Sampling expedition, as well as the revolution wrought at the individual laboratory level through next generation sequencing technologies. We review recent studies and discoveries since 2008, provide a discussion of bioinformatic analyses, including conceptual pipelines and sequence annotation and predict the future of metagenomics, with suggestions of collaborative community studies tailored toward answering some of the fundamental questions in marine microbial ecology.
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