赤眼蜂
毒素
真菌毒素
毒性
代谢物
生物
镰刀菌
免疫毒素
药理学
微生物学
化学
生物化学
细胞毒性
食品科学
体外
园艺
有机化学
作者
Yanshen Li,Zhanhui Wang,Ross C. Beier,Jianzhong Shen,David De Smet,Sarah De Saeger,Suxia Zhang
摘要
This review focuses on the toxicity and metabolism of T-2 toxin and analytical methods used for the determination of T-2 toxin. Among the naturally occurring trichothecenes in food and feed, T-2 toxin is a cytotoxic fungal secondary metabolite produced by various species of Fusarium. Following ingestion, T-2 toxin causes acute and chronic toxicity and induces apoptosis in the immune system and fetal tissues. T-2 toxin is usually metabolized and eliminated after ingestion, yielding more than 20 metabolites. Consequently, there is a possibility of human consumption of animal products contaminated with T-2 toxin and its metabolites. Several methods for the determination of T-2 toxin based on traditional chromatographic, immunoassay, or mass spectroscopy techniques are described. This review will contribute to a better understanding of T-2 toxin exposure in animals and humans and T-2 toxin metabolism, toxicity, and analytical methods, which may be useful in risk assessment and control of T-2 toxin exposure.
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