医学
类风湿性关节炎
炎症
关节炎
骨重建
炎性关节炎
自然史
炎症反应
免疫学
病理
内科学
作者
Steven R. Goldring,P. Edward Purdue,Tania Crotti,Zhenxin Shen,Merrilee R. Flannery,Nikolaus Binder,F. Patrick Ross,Kevin P. McHugh
标识
DOI:10.1136/annrheumdis-2012-202199
摘要
The inflammatory arthropathies that include rheumatoid arthritis, the seronegative spondyloarthropathies and systemic lupus erythematosus are characterised by marked alterations in the architecture and structural integrity of peri-articular bone; however, the pattern and natural history of the skeletal changes differs in these conditions. In part, this can be attributed to differences in the primary anatomical site of the inflammation, but also there is evidence that there are differences in the biological properties and products produced by inflammatory tissues. This review will focus on recent advances in the understanding of the cellular and molecular mechanisms that contribute to the differential pattern of articular bone remodelling in these prototypical inflammatory forms of arthritis.
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