核糖开关
适体
计算生物学
核糖核酸
指数富集配体系统进化
生物
选择(遗传算法)
非编码RNA
化学
遗传学
基因
作者
S.D. Gilbert,Robert T. Batey
标识
DOI:10.1007/s00018-005-5345-3
摘要
Advances in our knowledge of the structure and chemistry of RNA have been harnessed in the process known as SELEX to develop artificial RNA-based molecules that can act as enzymes and ligand binders performing a wide variety of functions. The discovery of riboswitches, natural RNA aptamers involved in genetic regulation, offers a basis of comparison between the artificial selection and the natural selection of structured RNAs for small-molecule recognition. The guanine riboswitch structural determination allows us to draw conclusions regarding the apparent increased complexity of the riboswitch aptamers compared to their in-vitro-selected cousins.
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