Oncostatin M pathway plays a major role in the renal acute phase response

肿瘤抑制因子 急性期蛋白 细胞因子 急性肾损伤 白细胞介素6 医学 脂多糖 内科学 免疫学 内分泌学 药理学 炎症
作者
Valérie A. Luyckx,Lucas V. Cairo,Catharine A. Compston,Wai Lee Phan,Thomas Mueller
出处
期刊:American Journal of Physiology-renal Physiology [American Physical Society]
卷期号:296 (4): F875-F883 被引量:36
标识
DOI:10.1152/ajprenal.90633.2008
摘要

The acute phase response is traditionally characterized by hepatic synthesis of proteins as an inflammatory response to injury, with interleukin-6 (IL-6) being the key mediator. In contrast, microarray studies in human renal transplant implantation biopsies indicate a strong acute phase response in the deceased donor kidney, associated with a significant upregulation of oncostatin M receptor beta (OSMR). The aim of this study was to determine whether the kidney can generate a strong acute phase response, mediated by the OSM/OSMR gateway. Genes associated with the IL-6 cytokine family and acute phase reactants were analyzed by real-time RT-PCR in four groups of human biopsies spanning a spectrum of renal injury. OSM, OSMR, and fibrinogen beta (FGB) were progressively more highly expressed from prenephrectomy, living donor, deceased donor, to discarded donor kidneys, suggesting correlation with severity of injury and local renal synthesis. Acute phase response gene expression was analyzed in human proximal tubular cells in culture in response to OSM. OSM induced a significant increase in expression of FGB, OSMR, serpin peptidase inhibitor A1, IL-6, and lipopolysaccharide binding protein, and a decrease in IL-6R. These changes were largely attenuated by coincubation with an OSMR blocking antibody, indicating the OSM effect was mediated through OSMR. OSM also resulted in a significantly altered expression of acute phase genes compared with IL-6 or leukemia inhibitory factor, suggesting that OSM is the predominant cytokine mediating the renal tubular acute phase response. In conclusion, the renal parenchyma is capable of generating a strong acute phase response, likely mediated via OSM/OSMR.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
余杭村王小虎完成签到,获得积分10
刚刚
打打应助594612采纳,获得10
1秒前
wdh完成签到,获得积分10
1秒前
waoller1发布了新的文献求助10
1秒前
waoller1发布了新的文献求助10
1秒前
砰砰里发布了新的文献求助30
1秒前
Micahaeler发布了新的文献求助10
2秒前
2秒前
bc应助阿椿采纳,获得30
3秒前
waoller1发布了新的文献求助10
3秒前
waoller1发布了新的文献求助10
3秒前
waoller1发布了新的文献求助10
3秒前
waoller1发布了新的文献求助10
3秒前
waoller1发布了新的文献求助10
3秒前
waoller1发布了新的文献求助10
3秒前
waoller1发布了新的文献求助10
3秒前
waoller1发布了新的文献求助10
3秒前
黄瓜儿发布了新的文献求助10
4秒前
氧泡泡发布了新的文献求助10
4秒前
4秒前
5秒前
CodeCraft应助和谐的天宇采纳,获得10
5秒前
5秒前
Ziyi_Xu发布了新的文献求助30
5秒前
李fr发布了新的文献求助10
6秒前
巡音幻夜完成签到,获得积分10
6秒前
7秒前
领导范儿应助海洋球采纳,获得10
8秒前
英姑应助张彩红采纳,获得10
9秒前
苗条辣条发布了新的文献求助10
9秒前
出其东门发布了新的文献求助10
9秒前
9秒前
小蘑菇应助小心科研采纳,获得10
9秒前
renxy应助Avert.采纳,获得10
9秒前
科研通AI2S应助loser采纳,获得10
10秒前
外向的飞雪完成签到,获得积分10
10秒前
善良豌豆完成签到,获得积分20
10秒前
嗷嗷嗷啊发布了新的文献求助10
10秒前
znn发布了新的文献求助10
11秒前
12秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974643
求助须知:如何正确求助?哪些是违规求助? 3519094
关于积分的说明 11196979
捐赠科研通 3255182
什么是DOI,文献DOI怎么找? 1797700
邀请新用户注册赠送积分活动 877100
科研通“疑难数据库(出版商)”最低求助积分说明 806130