化学
色谱法
光刻
离子色谱法
检出限
分析化学(期刊)
柱色谱法
炸薯条
分析物
硫脲
纳米技术
材料科学
电气工程
工程类
有机化学
作者
John P. Murrihy,Michael C. Breadmore,Aimin Tan,Máiréad McEnery,J. Alderman,Cian O’Mathuna,Alan P. O’Neill,P. O'Brien,Nebjosa Advoldvic,Paul R. Haddad,Jeremy D. Glennon
标识
DOI:10.1016/s0021-9673(01)00855-x
摘要
On-chip separation of inorganic anions by ion-exchange chromatography was realized. Micro separation channels were fabricated on a silicon wafer and sealed with a Pyrex cover plate using standard photolithography, wet and dry chemical etching, and anodic bonding techniques. Quaternary ammonium latex particles were employed for the first time to coat the separation channels on-chip. Owing to the narrow depths of the channels on the chip, 0.5-10 microm, there were more interactions of the analytes with the stationary phase on the chip than in a 50-microm I.D. capillary. With off-chip injection (20 nl) and UV detection, NO2-, NO3-, I-, and thiourea were separated using 1 mM KCl as the eluent. The linear ranges for NO2- and NO3- are from 5 to 1000 microM with the detection limits of 0.5 microM.
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