乳腺癌
医学
内科学
维生素E
辅助治疗
肿瘤科
队列
癌症
比例危险模型
胃肠病学
疾病
维生素C
抗氧化剂
生物
生物化学
作者
Monique Saintot,Hélène Mathieu‐Daudé,Cécile Astre,Jean Grenier,Joëlle Simony-Lafontaine,Mariette Gerber
摘要
Abstract The role of plasma oxidant‐antioxidant status in survival after breast cancer surgery was investigated in a cohort of patients ( n = 363) hospitalized in Southern France between 1989 and 1992. The median follow‐up was 8 years after surgery for histologically confirmed breast cancer. Plasma analyses were performed after diagnosis and before surgery and adjuvant therapy. We found an inverse relationship between plasma lipoperoxides (MDA) and tumor size at diagnosis, together with higher lipoperoxide levels in node‐negative tumors than in node‐positive ones (TNM). The longitudinal approach revealed an increased risk of recurrence for patients with plasma lipoperoxides in the highest tertile of the sample (RR = 2.1, 95%CI 1.1–4.0). In addition, the risk of recurrence increased (RR = 1.7, 95%CI 1.0–3.0), after adjustment for the known prognostic factors (TNM), for patients with plasma lipid‐adjusted vitamin E levels of over 22 μmol/l. The risk of breast cancer death was twice as great for patients with plasma lipid‐adjusted vitamin E levels above this value. Excesses of plasma lipoperoxides and vitamin E appear to be factors in poor prognosis for breast cancer‐specific survival (OVS) and disease‐free survival (DFS), respectively, independent of tumor characteristics at diagnosis. Several hypotheses are advanced to explain the possible role of plasma vitamin E as a factor in poor prognosis for survival. © 2001 Wiley‐Liss, Inc.
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