化学
酮
受体
敌手
配体(生物化学)
孕酮受体
类固醇
选择性
立体化学
化学合成
甲酰胺
配体结合分析
体外
生物化学
激素
内科学
有机化学
癌症
催化作用
雌激素受体
乳腺癌
医学
作者
Yongli Du,Qunyi Li,Bing Xiong,Hui Xin,Wei Wang,Yang Feng,Tao Meng,Dingyu Hu,Datong Zhang,Ming‐Wei Wang,Jingkang Shen
标识
DOI:10.1016/j.bmc.2010.04.092
摘要
A novel class of non-steroidal progesterone receptor antagonists with aromatic beta-amino-ketone scaffold have been synthesized and characterized with high binding affinity and great selectivity for the cognate receptors. Among them, compound 22 was shown to be the most potent progesterone receptor antagonist in cotransfection assay and a murine model of ligand-induced decidualization.
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