润湿
接触角
原子力显微镜
化学
疏水效应
纳米技术
纳米尺度
疏水
化学工程
力谱学
化学物理
材料科学
有机化学
生物化学
工程类
作者
David Alsteens,Étienne Dague,Paul G. Rouxhet,Alain R. Baulard,Yves F. Dufrêne
出处
期刊:Langmuir
[American Chemical Society]
日期:2007-10-17
卷期号:23 (24): 11977-11979
被引量:158
摘要
Although hydrophobic forces are of great relevance in biological systems, quantifying these forces on complex biosurfaces such as cell surfaces has been difficult owing to the lack of appropriate, ultrasensitive force probes. Here, chemical force microscopy (CFM) with hydrophobic tips was used to measure local hydrophobic forces on organic surfaces and on live bacteria. On organic surfaces, we found an excellent correlation between nanoscale CFM and macroscale wettability measurements, demonstrating the sensitivity of the method toward hydrophobicity and providing novel insight into the nature of hydrophobic forces. Then, we measured hydrophobic forces associated with mycolic acids on the surface of mycobacteria, supporting the notion that these hydrophobic compounds represent an important permeation barrier to drugs.
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