Laboratory and Clinical Evaluation of a New Antibiotic—Cephalothin

Article1 August 1965Laboratory and Clinical Evaluation of a New Antibiotic—CephalothinMARVIN TURCK, M.D., KENNETH N. ANDERSON, M.D., RONALD H. SMITH, M.D, JAMES F. WALLACE, M.D., ROBERT G. PETERSDORF, M.D., F.A.C.P.MARVIN TURCK, M.D.Search for more papers by this author, KENNETH N. ANDERSON, M.D.Search for more papers by this author, RONALD H. SMITH, M.DSearch for more papers by this author, JAMES F. WALLACE, M.D.Search for more papers by this author, ROBERT G. PETERSDORF, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-2-199 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCephalothin, 7 (thiophene-2-acetamido)-cephalosporanic acid, is a semisynthetic derivative of cephalosporin C. Although the structures of the cephalothin nucleus (7-amino-cephalosporanic acid) and the penicillin nucleus (6-amino-penicillanic acid) are quite similar, there are numerous differences in the biologic behavior of these drugs, including apparent lack of cross allergenicity, resistance of cephalothin to degradation by penicillinase, and cephalothin's broader antimicrobial spectrum (1-7). Results of preliminary studies conducted in our laboratories in 1962 (8) suggested that cephalothin might be useful in diverse systemic infections and prompted further clinical trials. The present report is an extension of these original in vitro and in vivo observations...References1. BONIECEWICKHOLMESREDMAN WSWEDHCE: In vitro and in vivo laboratory evaluation of cephalothin, new broad spectrum antibiotic. J. Bact. 84: 1292, 1962. CrossrefMedlineGoogle Scholar2. CHANGWEINSTEIN TWL: In vitro biological activity of cephalothin. J. Bact. 85: 1022, 1963. CrossrefMedlineGoogle Scholar3.. WALTERSROMANSKYJOHNSON EWMJAC: Cephalothin, a new semisynthetic broad-spectrum antibiotic. Laboratory and clinical studies in 52 patients (preliminary report), in Antimicrobial Agents and Chemotherapy—1962. Braun-Brumfield, Inc., Ann Arbor, 1963, p. 706. Google Scholar4. PHILSONCLANCYALEXANDER JRCFJD: Cephalothin therapy in bacterial infections, in Antimicrobial Agents and Chemotherapy—1963. Braun-Brumfield, Inc., Ann Arbor, 1964, p. 267. Google Scholar5. WEINSTEINKAPLANCHANG LKTW: Treatment of infections in man with cephalothin. JAMA 189: 829, 1964. CrossrefMedlineGoogle Scholar6. GRIFFITHBLACK RSHR: Cephalothin—a new antibiotic—preliminary clinical and laboratory studies. Ibid., p. 823. Google Scholar7. WALTERSROMANSKYJOHNSON EWMJAC: Cephalothin—laboratory and clinical studies in 109 patients, in Antimicrobial Agents and Chemotherapy—1963. Braun-Brumfield, Inc., Ann Arbor, 1964, p. 247. Google Scholar8. ANDERSONPETERSDORF KNRG: Cephalosporin C and cephalothin in gram-negative infections, in Antimicrobial Agents and Chemotherapy—1962. Braun-Brumfield, Inc., Ann Arbor, 1963, p. 724. Google Scholar9. TURCKLINDEMEYERPETERSDORF MRIRG: Comparison of single-disk and tube-dilution techniques in determining antibiotic sensitivities of gram-negative pathogens. Ann. Intern. Med. 58: 56, 1963. LinkGoogle Scholar10. PETERSDORFBENNETTROSE RGILMC: The sensitivity of pathogenic bacteria to a series of antibiotics. Bull. Hopkins Hosp. 100: 1, 1957. MedlineGoogle Scholar11. BAUERPERRYKIRBY AWDMWM: Single-disk antibiotic sensitivity testing of staphylococci. Arch. Intern. Med. 104: 208, 1958. CrossrefGoogle Scholar12. EDWARDSEWING PRWH: In Identification of Enterobacteriaceae. Burgess, Minneapolis, 1955, p. 137. Google Scholar13. LINDEMEYERTURCKPETERSDORF RIMRG: Factors determining the outcome of chemotherapy in infections of the urinary tract. Ann. Intern. Med. 58: 201, 1963. LinkGoogle Scholar14. KLEINEICKHOFFTILLESFINLAND JOTCJGM: Cephalothin. Amer. J. Med. Sci. 248: 640, 1964. CrossrefMedlineGoogle Scholar15. TURCK M: Unpublished observations. Google Scholar16. ABRAHAM EP: In Biochemistry of Some Peptide and Steroid Antibiotics. J. Wiley and Sons, Inc. New York, 1957, p. 34. Google Scholar17. DAVISSELIGMANHEWITTFINEGOLD ASJWLSM: Neutropenic reaction to cephalothin therapy, in Antimicrobial Agents and Chemotherapy—1963. Braun-Brumfield, Inc., Ann Arbor, 1964, p. 272. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MARVIN TURCK, M.D.; KENNETH N. ANDERSON, M.D.; RONALD H. SMITH, M.D; JAMES F. WALLACE, M.D.; ROBERT G. PETERSDORF, M.D., F.A.C.P.Affiliations: Seattle, WashingtonFrom the Department of Medicine, University of Washington School of Medicine, and King County Hospital, Seattle, Wash.This study was supported by training grant AI 146-05 from the U. S. Public Health Service, Bethesda, Md., and a research grant from Lilly Laboratories, Indianapolis, Ind.Requests for reprints should be addressed to Marvin Turck, M.D., King County Hospital, 325 Ninth Ave., Seattle, Wash. 98104. 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BULGER, M.D.ANTIBACTERIAL ACTION OF "BROAD-SPECTRUM" PENICILLINS, CEPHALOSPORINS AND OTHER ANTIBIOTICS AGAINST GRAM-NEGATIVE BACILLI ISOLATED FROM BACTEREMIC PATIENTSLABORATORY DETERMINATION OF ANTIBIOTIC SUSCEPTIBILITY TO AMPICILLIN AND CEPHALOTHINBROAD-SPECTRUM PENICILLINS AND OTHER ANTIBIOTICS IN THE TREATMENT OF URINARY TRACT INFECTIONSDie therapie mit antibiotiea unter besonderer ber�cksichtigung ihrer beziehungen zur Hals-Nasen-Ohren-HeilkundeAntimicrobial therapy in patients sensitive to penicillinCurrent Therapy of Bacterial PneumoniasThe Klebsiella-Enterobacter-Serratia Division Biochemical and Serologic Characteristics and Susceptibility to AntibioticsTHEODORE C. EICKHOFF, M.D., BRUCE W. STEINHAUER, M.D., MAXWELL FINLAND, M.D., F.A.C.P.KANAMYCIN IN URINARY TRACT INFECTIONSThe Treatment of Infections in Patients with Neoplasia Undergoing SurgeryMethods and significance of in vitro testing of bacterial sensitivity to drugsManagement of staphylococcal infections 1 August 1965Volume 63, Issue 2Page: 199-211KeywordsAttentionEscherichia coliHospital medicinePenicillinPseudomonasResearch grantsResearch laboratoriesStaphylococcal infectionStreptococcal infectionsUrinary tract infections ePublished: 1 December 2008 Issue Published: 1 August 1965 PDF downloadLoading ...