医学
安慰剂
内科学
便秘
中止
慢性便秘
不利影响
胃肠病学
临床终点
随机对照试验
病理
替代医学
作者
Anthony Lembo,Harvey Schneier,Steven J. Shiff,Allen W. Mangel,James E. MacDougall,Xinwei D. Jia,James Shao,Bernard J. Lavins,Mark G. Currie,Donald A. Fitch,Brenda I. Jeglinski,Paul Eng,Susan M. Fox,Jeffrey M. Johnston
标识
DOI：10.1056/nejmoa1010863
摘要
Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients with chronic constipation.
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