小细胞细胞
下丘脑
电生理学
核心
内科学
生物
神经科学
内分泌学
细胞体
中枢神经系统
医学
作者
Jason A. Luther,Shabrine S. Daftary,Chérif Boudaba,Grahame Gould,Katalin Cs. Halmos,Jeffrey G. Tasker
标识
DOI:10.1046/j.1365-2826.2002.00867.x
摘要
Parvocellular neurones of the hypothalamic paraventricular nucleus (PVN) comprise neurosecretory and non-neurosecretory subpopulations. We labelled neurosecretory neurones with intravenous injection of the retrograde tracer, fluoro-gold, and recorded from fluoro-gold-positive and negative PVN parvocellular neurones in hypothalamic slices. Non-neurosecretory parvocellular neurones generated a low-threshold spike (LTS) and robust T-type Ca2+ current, whereas neurosecretory neurones showed no LTS and a small T-current. LTS neurones were located in non-neurosecretory regions of the PVN, and non-LTS neurones were located in neurosecretory regions of the PVN. These findings indicate that neurosecretory and non-neurosecretory subtypes of parvocellular PVN neurones express distinct membrane electrical properties.
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