已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Atrial electrophysiological remodeling caused by rapid atrial activation: underlying mechanisms and clinical relevance to atrial fibrillation

心房颤动 内科学 心脏病学 医学 电生理学 心房动作电位 房性心动过速 导管消融 复极
作者
Stanley Nattel
出处
期刊:Cardiovascular Research [Oxford University Press]
卷期号:42 (2): 298-308 被引量:147
标识
DOI:10.1016/s0008-6363(99)00022-x
摘要

One of the most exciting developments in our understanding of atrial fibrillation (AF) over the last several years has been the recognition that AF itself modifies atrial electrical properties in a way that promotes the occurrence and maintenance of the arrhythmia, a process termed 'atrial remodeling'. The principle stimulus for AF-induced atrial remodeling is the rapid atrial rate that results: rapid regular atrial pacing produces changes similar to those caused by AF in animal models. The mechanisms of atrial tachycardia-induced remodeling have been extensively explored, and involve changes in atrial electrophysiology associated with altered ion channel function. The most important ionic change is a reduction in L-type Ca2+ current, which reduces action potential duration (APD) and APD adaptation to rate. AF-induced changes in ion channel function appear to be due both to rapid voltage- and time-dependent alterations in channel availability caused by tachycardia and to slower downregulation of messenger RNA concentrations encoding α-subunits of specific ion channels. Atrial remodeling likely contributes importantly to a wide variety of clinical phenomena of previously unrecognized mechanism, including atrial dysfunction after cardioversion of AF, the increasing resistance to therapy of longer-standing AF, the association of AF with other forms of supraventricular tachyarrhythmia and the tendency of paroxysmal AF to become chronic. The present paper reviews the state of knowledge regarding the mechanisms and clinical consequences for AF of atrial remodeling caused by rapid atrial activation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
恋雅颖月应助miles采纳,获得10
1秒前
1秒前
岂曰无衣完成签到 ,获得积分10
1秒前
大模型应助victoria采纳,获得10
3秒前
大头发布了新的文献求助10
5秒前
5秒前
赵杰发布了新的文献求助10
6秒前
7秒前
予秋发布了新的文献求助10
7秒前
momo发布了新的文献求助10
7秒前
我是老大应助瘦瘦语蕊采纳,获得10
11秒前
大面包发布了新的文献求助10
11秒前
13秒前
QTQ发布了新的文献求助10
13秒前
14秒前
怕黑大白菜真实的钥匙完成签到,获得积分10
14秒前
EMM完成签到 ,获得积分10
16秒前
16秒前
18秒前
victoria发布了新的文献求助10
19秒前
19秒前
不呐呐发布了新的文献求助10
20秒前
whatever应助喏晨采纳,获得10
20秒前
瓦学弟的妈妈完成签到 ,获得积分20
21秒前
负责怀莲发布了新的文献求助10
21秒前
22秒前
温柔烧鹅完成签到,获得积分10
22秒前
24秒前
Thea发布了新的文献求助30
25秒前
温柔烧鹅发布了新的文献求助10
25秒前
26秒前
瘦瘦语蕊发布了新的文献求助10
26秒前
28秒前
为医消得人憔悴完成签到 ,获得积分10
28秒前
zjgjnu发布了新的文献求助10
29秒前
29秒前
30秒前
Peter发布了新的文献求助10
31秒前
瘦瘦语蕊完成签到,获得积分10
34秒前
35秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989857
求助须知:如何正确求助?哪些是违规求助? 3531994
关于积分的说明 11255679
捐赠科研通 3270758
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882195
科研通“疑难数据库(出版商)”最低求助积分说明 809208