A Comparison of Liver Function After Hepatectomy with Inflow Occlusion Between Sevoflurane and Propofol Anesthesia

七氟醚 医学 异丙酚 麻醉 肝切除术 肝功能 胆红素 肝功能检查 丙氨酸转氨酶 背景(考古学) 天冬氨酸转氨酶 外科 内科学 碱性磷酸酶 切除术 化学 古生物学 生物 生物化学
作者
Jin‐Chao Song,Yijuan Sun,Liqun Yang,M. Z. Zhang,Zhijie Lu,Wenlong Yu
出处
期刊:Anesthesia & Analgesia [Lippincott Williams & Wilkins]
卷期号:111 (4): 1036-1041 被引量:32
标识
DOI:10.1213/ane.0b013e3181effda8
摘要

In this study, we compared liver function tests after hepatectomy with inflow occlusion as a function of propofol versus sevoflurane anesthesia.One hundred patients undergoing elective liver resection with inflow occlusion were randomized into a sevoflurane group or a propofol group. General anesthesia was induced with 3 μg/kg fentanyl, 0.2 mg/kg cisatracurium, and target-controlled infusion of propofol, set at a plasma target concentration of 4 to 6 μg/mL, or sevoflurane initially started at 8%. Anesthesia was maintained with target-controlled infusion of propofol (2-4 μg/mL) or sevoflurane (1.5%-2.5%). The primary end point was postoperative liver injury assessed by peak values of liver transaminases.Transaminase levels peaked between the first and the third postoperative day. Peak alanine aminotransferase was 504 and 571 U/L in the sevoflurane group and the propofol group, respectively. Peak aspartate aminotransferase was 435 U/L after sevoflurane and 581 U/L in the propofol group. There were no significant differences in peak alanine aminotransferase or peak aspartate aminotransferase between groups. Other liver function tests including bilirubin and alkaline phosphatase, and peak values of white blood cell counts and creatinine, were also not different between groups.Sevoflurane and propofol anesthetics resulted in similar patterns of liver function tests after hepatectomy with inflow occlusion. These data suggest that the 2 anesthetics are equivalent in this clinical context.
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