多塞平
抗焦虑药
安慰剂
焦虑
医学
交叉研究
麻醉
血压
心率
心理学
内科学
精神科
替代医学
病理
作者
Pierre Assalian,M Rosengarten,Robert A. Phillips
出处
期刊:PubMed
日期:1985-03-01
卷期号:46 (3): 90-4
被引量:11
摘要
After a 1-week placebo washout, 25 depressed hospitalized patients were treated for 4 weeks with trimipramine or doxepin in a fixed equivalent dosage schedule ending in 150 mg h.s. The study used a parallel group double-blind design. Comparisons over time revealed that both drugs improved patients' overall well-being as indicated by the rating scales studied. Significant (p less than .05) differences between the treatments favored trimipramine over doxepin: the Hamilton scale diurnal variation cluster at Week 1 and the sleep disturbance factor at Week 4; the Clinical Global Impressions improvement index at Week 1; and the Anxiety Status Inventory somatic symptoms cluster at Week 4. No differences in blood pressure, heart rate, PVCs, or PACs were observed in any of the comparisons. The total number of side effects reported was greater in the doxepin-treated patients.
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