生物传感器
葡萄糖氧化酶
抗坏血酸
锇
戊二醛
氧化还原
检出限
辣根过氧化物酶
化学
线性范围
制作
过氧化物酶
聚合物
材料科学
纳米技术
色谱法
无机化学
生物化学
有机化学
催化作用
医学
替代医学
食品科学
病理
钌
酶
摘要
The fabrication and analytical characterization of an osmium redox polymer modified glucose biosensor for measurement of low concentration glucose is described. The thin film gold electrode was modified with osmium redox polymer wired horseradish peroxidase and immobilization of the glucose oxidase was then operated using glutaraldehyde to build the glucose sensor. The developed sensor characterized a low background current less than 1 nA and a detection limit of 1 μM, as well as a high sensitivity of 2900 nA μM-1 in the linear range up to 400 μM at low applied potential of -0.1 V (vs. Ag|AgCl). The oxidation interference of ascorbic acid for the determination of glucose can be prevented due to the low applied potential. These results testified the feasibility of the sensor for measurement of low concentration glucose and have significance for the development of noninvasive glucose monitoring system for the control of diabetes.
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