Primary synovial sarcoma of the scalp: Report of case with a clinicopathological and molecular cytogenetic study

Synovial sarcoma (SS) arising primarily in the scalp was scarcely reported. Here we described a subcutaneous mass in the right parietal region of the scalp of a 39 year-old male patient. It has been present for 10 years and enlarged recently. It was initially suspected as hemangioma by magnetic resonance imaging (MRI), but the histological examination revealed a sarcoma rich of spindle cells reminiscent of SS. Therefore, immunohistochemistry, florescence in site hybridization (FISH), reverse transcription-polymerase chain reaction (RT-PCR) and DNA sequencing were performed to determine the final diagnosis as biphasic SS. The detailed description of primary scalp SS might help differential diagnosis of scalp soft tumors.