医学
经皮冠状动脉介入治疗
氯吡格雷
内科学
阿司匹林
急性冠脉综合征
传统PCI
心脏病学
心肌梗塞
弗雷明翰风险评分
药物洗脱支架
血栓形成
支架
狼牙棒
作者
Usman Baber,Roxana Mehran,Gennaro Giustino,David J. Cohen,Timothy D. Henry,Samantha Sartori,Cono Ariti,Claire Litherland,George Dangas,C. Michael Gibson,Mitchell W. Krucoff,David J. Moliterno,Ajay J. Kirtane,Gregg W. Stone,Antonio Colombo,Alaide Chieffo,Annapoorna Kini,Bernhard Witzenbichler,Giora Weisz,Philippe Gabriel Steg,Stuart J. Pocock
标识
DOI:10.1016/j.jacc.2016.02.064
摘要
Dual-antiplatelet therapy with aspirin and clopidogrel after percutaneous coronary intervention reduces the risk for coronary thrombotic events (CTEs) at the expense of increasing risk for major bleeding (MB). Metrics to accurately predict the occurrence of each respective event and inform clinical decision making are lacking.The aim of this study was to develop and validate separate models to predict risks for out-of-hospital thrombotic and bleeding events after percutaneous coronary intervention with drug-eluting stents.Using data from 4,190 patients treated with drug-eluting stents and enrolled in the PARIS (Patterns of Non-Adherence to Anti-Platelet Regimen in Stented Patients) registry, separate risk scores were developed to predict CTE (defined as the composite of stent thrombosis or myocardial infarction) and MB (defined as the occurrence of a Bleeding Academic Research Consortium type 3 or 5 bleed). External validation was performed in the ADAPT-DES (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) registry.Over 2 years, CTEs occurred in 151 patients (3.8%) and MB in 133 (3.3%). Independent predictors of CTEs included acute coronary syndrome, prior revascularization, diabetes mellitus, renal dysfunction, and current smoking. Independent predictors of MB included older age, body mass index, triple therapy at discharge, anemia, current smoking, and renal dysfunction. Each model displayed moderate levels of discrimination and adequate calibration.Simple risk scores of baseline clinical variables may be useful to predict risks for ischemic and bleeding events after PCI with DES, thereby facilitating clinical decisions surrounding the optimal duration of DAPT. (Patterns of Non-Adherence to Anti-Platelet Regimen in Stented Patients [PARIS]; NCT00998127).
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