P150GLP-1 (7-36) prevents palmitate-induced oxidative stress in HL-1 cardiomyocytes

Aims: Lipotoxicity increases oxidative stress and induces mitochondrial alterations in cardiomyocytes, contributing to left ventricular dysfunction in diabetic cardiomyopathy. GLP-1 is an incretin reported to have anti-oxidant actions in different cellular models. We investigated whether GLP-1 inhibits oxidative stress, mitochondrial dysfunction and DNA oxidative damage in murine HL-1 cardiomyocytes stimulated with palmitate.