核苷酸
化学
硼
脱氧尿苷
核苷
胸苷
核磁共振波谱
立体化学
有机化学
生物化学
DNA
基因
作者
Joanna Nizioł,Tomasz Ruman
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2013-09-01
卷期号:10 (9): 664-667
标识
DOI:10.2174/15701786113109990030
摘要
The routes of synthesis of the new boron nucleosides – 3’,5’-cyclic boron esters of 2’-deoxycytidine, 2’- deoxyuridine and thymidine along with 3’,5’-bis(pinacolborate) derivatives of 2’-deoxyuridine, 5-fluoro-2’-deoxyuridine and thymidine are presented. The 1H-, 13C- and 11B NMR data of new boron nucleosides are compared with their precursors NMR properties. Presented compounds are in fact boron analogs of nucleotides where boron is in the position of phosphorus atom. New compounds should be at interesting positions as new building blocks in nucleoside and nucleotide chemistry. Keywords: Boron nucleotides, cyclic nucleotides, boron nucleosides.
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