Indium Tri(isopropoxide)-Catalyzed Selective Meerwein–Ponndorf–Verley Reduction of Aliphatic and Aromatic Aldehydes

Indium tri(isopropoxide)-catalyzed Meerwein–Ponndorf–Verley reduction of aliphatic and aromatic aldehydes in 2-propanol gave selectively the corresponding primary alcohols in good to excellent yields at room temperature. A wide range of functional groups including alkene, ether, ketone, ester, nitrile, and nitro were tolerated under the optimum reaction conditions. Chemoselective reductions were also achieved not only between aromatic aldehyde, aromatic ketone, and epoxide but also between aliphatic aldehyde and alkene.