2,2,2‐Trifluoroethyl Oxalates in the One‐Pot Parallel Synthesis of Hindered Aliphatic Oxamides

Abstract A simple parallel synthesis approach to unsymmetrical N 1 , N 2 ‐substituted aliphatic oxamides using methyl (2,2,2‐trifluoroethyl) oxalate and bis(2,2,2‐trifluoroethyl) oxalate was developed. The method was validated on a 52‐membered set of the oxamides, derived mainly from hindered primary and secondary aliphatic amines, and gave the products with a high overall success rate in moderate yields.