Multifocal disease in the upper genital canal.

Multifocal disease, both benign and malignant, is seen commonly in the lower genital canal. Conversely, malignancies developing concomitantly in the uterus and ovary are frequently diagnosed as metastatic disease. In this series of 54 cases, the overall five-year survival was 72%, and 90% when the lesions were limited to the uterus and ovary, demonstrating that these lesions are multifocal and not metastatic. Furthermore, the frequency with which endometriosis is found in association with these malignancies dictates that the adjunctive therapy should probably be progesterone in most instances.