扁桃形结构
心理学
功能磁共振成像
面部表情
价(化学)
神经科学
意识的神经相关物
反应性(心理学)
听力学
认知
沟通
医学
替代医学
物理
量子力学
病理
作者
Michael S. McCloskey,K. Luan Phan,Mike Angstadt,Karla C. Fettich,Sarah K. Keedy,Emil F. Coccaro
标识
DOI:10.1016/j.jpsychires.2016.04.006
摘要
Individuals with intermittent explosive disorder (IED) were previously found to exhibit amygdala hyperactivation and relatively reduced orbital medial prefrontal cortex (OMPFC) activation to angry faces while performing an implicit emotion information processing task during functional magnetic resonance imaging (fMRI). This study examines the neural substrates associated with explicit encoding of facial emotions among individuals with IED. Twenty unmedicated IED subjects and twenty healthy, matched comparison subjects (HC) underwent fMRI while viewing blocks of angry, happy, and neutral faces and identifying the emotional valence of each face (positive, negative or neutral). We compared amygdala and OMPFC reactivity to faces between IED and HC subjects. We also examined the relationship between amygdala/OMPFC activation and aggression severity. Compared to controls, the IED group exhibited greater amygdala response to angry (vs. neutral) facial expressions. In contrast, IED and control groups did not differ in OMPFC activation to angry faces. Across subjects amygdala activation to angry faces was correlated with number of prior aggressive acts. These findings extend previous evidence of amygdala dysfunction in response to the identification of an ecologically-valid social threat signal (processing angry faces) among individuals with IED, further substantiating a link between amygdala hyperactivity to social signals of direct threat and aggression.
科研通智能强力驱动
Strongly Powered by AbleSci AI