Clinical pharmacokinetics (PK) of EZN-2208, a novel anticancer agent, in patients (pts) with advanced malignancies: A phase I, first-in-human, dose-escalation study
医学
药代动力学
最大耐受剂量
药理学
内科学
作者
Z. Guo,Jennifer J. Wheler,Aung Naing,Sridhar Mani,Sanjay Goel,Mary F. Mulcahy,F. Gamza,C. Longley,Aby Buchbinder,R. Kurzrock
2556 Background: EZN-2208 is a water-soluble, polyethylene glycol (PEG) conjugate of SN38 that is active in solid tumors and lymphoma preclinical models, including an in vivo CPT-11-resistant tumor...
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