表观遗传学
染色质
神经发生的表观遗传调控
生物
DNA甲基化
串扰
组蛋白
表观遗传学
后生
计算生物学
癌症表观遗传学
遗传学
体育锻炼的表观遗传学
细胞生物学
染色质重塑
DNA
基因表达
基因
组蛋白甲基转移酶
物理
光学
作者
Joanna K. Lempiäinen,Benjamin A. García
摘要
Epigenetics, the inheritance of genomic information independent of DNA sequence, controls the interpretation of extracellular and intracellular signals in cell homeostasis, proliferation and differentiation. On the chromatin level, signal transduction leads to changes in epigenetic marks, such as histone post-translational modifications (PTMs), DNA methylation and chromatin accessibility to regulate gene expression. Crosstalk between different epigenetic mechanisms, such as that between histone PTMs and DNA methylation, leads to an intricate network of chromatin-binding proteins where pre-existing epigenetic marks promote or inhibit the writing of new marks. The recent technical advances in mass spectrometry (MS) -based proteomic methods and in genome-wide DNA sequencing approaches have broadened our understanding of epigenetic networks greatly. However, further development and wider application of these methods is vital in developing treatments for disorders and pathologies that are driven by epigenetic dysregulation.
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