珊瑚
生物测定
抗菌活性
最小抑制浓度
立体化学
屎肠球菌
细菌
化学
微生物学
耐万古霉素肠球菌
体外
生物
抗生素
生物化学
金黄色葡萄球菌
万古霉素
生态学
遗传学
作者
Ting Xu,Qingmin Zhao,Li‐Gong Yao,Lefu Lan,Song‐Wei Li,Yue‐Wei Guo
出处
期刊:Steroids
[Elsevier]
日期:2023-01-13
卷期号:192: 109182-109182
被引量:1
标识
DOI:10.1016/j.steroids.2023.109182
摘要
Four new steroids, namely sinulasterols D–G (1–4), along with seven known related ones 5–11, were isolated from the Xisha soft coral Sinularia depressa. The structures of the new compounds were elucidated by a combination of extensive spectroscopic analyses, chemical conversion method, and comparison of the NMR data with those of known analogues. In in vitro bioassays, compounds 1–3 showed significant antibacterial activities against gram-positive bacteria Enterococcus faecium with minimum inhibitory concentration (MIC) values of 62.5, 125, and 125 µM, respectively, comparable with that of vancomycin (MIC: >44.2 µM).
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