神经科学
疾病
睡眠(系统调用)
医学
生物
内科学
计算机科学
操作系统
作者
M. Yang,Yan Zhang,Yuxian Zheng,Guang He,Zhi‐Xiang Xu,Xiao Xiao,Yong Ping
标识
DOI:10.1002/advs.202411768
摘要
While animals across species typically experience suppressed consciousness and an increased arousal threshold during sleep, the responsiveness to specific sensory inputs persists. Previous studies have demonstrated that rhythmic and continuous vibration can enhance sleep in both animals and humans. However, the neural circuits underlying vibration-induced sleep (VIS) and its potential therapeutic benefits on neuropathological processes in disease models remain unclear. Here, it is shown that intermittent vibration, such as cycles of 30 s on followed by 30 s off, is more effective in inducing sleep compared to continuous vibration. A clear evidence is further provided that allatostatin A (AstA)-GABA signaling mediates short-term intermittent vibration-induced sleep (iVIS) by inhibiting octopaminergic arousal neurons through activating GABA
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