益生元
肠道菌群
代谢途径
脂质代谢
新陈代谢
信号转导
生物
微生物代谢
生物化学
化学
细菌
遗传学
作者
Yue Xiao,Dongmei Yang,Haoran Zhang,Huan Guo,Ying Liao,Changhong Lian,Yuqin Yao,Hong Gao,Yina H. Huang
标识
DOI:10.1021/acs.jafc.3c08541
摘要
The dysregulation of lipid metabolism poses a significant health threat, necessitating immediate dietary intervention. Our previous research unveiled the prebiotic-like properties of theabrownin. This study aimed to further investigate the theabrownin-gut microbiota interactions and their downstream effects on lipid metabolism using integrated physiological, genomic, metabolomic, and transcriptomic approaches. The results demonstrated that theabrownin significantly ameliorated dyslipidemia, hepatic steatosis, and systemic inflammation induced by a high-fat/high-cholesterol diet (HFD). Moreover, theabrownin significantly improved HFD-induced gut microbiota dysbiosis and induced significant alterations in microbiota-derived metabolites. Additionally, the detailed interplay between theabrownin and gut microbiota was revealed. Analysis of hepatic transcriptome indicated that FoxO and PPAR signaling pathways played pivotal roles in response to theabrownin-gut microbiota interactions, primarily through upregulating hepatic
科研通智能强力驱动
Strongly Powered by AbleSci AI