再生(生物学)
细胞生物学
组织修复
巨噬细胞
化学
生物
生物化学
体外
作者
Rong Nie,Qingyi Zhang,Zi-Yuan Feng,Kai Huang,Chen‐Yu Zou,Ming‐Hui Fan,Yueqi Zhang,J. Z. Zhang,Jesse Li‐Ling,Bo Tan,Huiqi Xie
标识
DOI:10.1016/j.ijbiomac.2024.131643
摘要
The rational design of hydrogel materials to modulate the immune microenvironment has emerged as a pivotal approach in expediting tissue repair and regeneration. Within the immune microenvironment, an array of immune cells exists, with macrophages gaining prominence in the field of tissue repair and regeneration due to their roles in cytokine regulation to promote regeneration, maintain tissue homeostasis, and facilitate repair. Macrophages can be categorized into two types: classically activated M1 (pro-inflammatory) and alternatively activated M2 (anti-inflammatory and pro-repair). By regulating the physical and chemical properties of hydrogels, the phenotypic transformation and cell behavior of macrophages can be effectively controlled, thereby promoting tissue regeneration and repair. A full understanding of the interaction between hydrogels and macrophages can provide new ideas and methods for future tissue engineering and clinical treatment. Therefore, this paper reviews the effects of hydrogel components, hardness, pore size, and surface morphology on cell behaviors such as macrophage proliferation, migration, and phenotypic polarization, and explores the application of hydrogels based on macrophage immune regulation in skin, bone, cartilage, and nerve tissue repair. Finally, the challenges and future prospects of macrophage-based immunomodulatory hydrogels are discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI