Due to the recent experience of SARS-CoV-2, health care has become the most important thing for everyone worldwide. As a consequence, it has become essential to make smart clothing with built-in bionanosensors and communication technology that can be used in health care to protect people and save their lives. In this chapter, we have described recent developments in smart clothing and communication technologies. We have described the building blocks of communication technology, such as the material substrates for smart clothing, wearable sensors, decision-making units, and power generation units. Most wearable technology comprises electrical devices that can connect to other devices and the person wearing them. Modern textile fibres, microelectronics, biotechnology, and artificial intelligence can all be used to make smart clothing. This chapter talks about personal communication, wide-area networks, monitoring systems and services, as well as opportunities and problems; at the end of the chapter, we looked at an example of how smart clothing made from silk fibroin, the natural resource of polymers, can be used in communication technologies.