Comparison of Changes in Retinal Vascular Parameters and density in patients with Moyamoya disease: A retrospective Study

Objective: This study aims to compare retinal vascular parameters and density in patients with Moyamoya disease using the optical coherence tomography angiography. Patients and Methods: This clinical trial totally enrolls 78 eyes from 39 participants, and all these patients with Moyamoya disease (N=13) are set as experimental group and participants with health who matched with age and gender are considered as the control group (N=26). Then all these participants receive Optical coherence tomography angiography detection. Participants’ general data are collected and analyzed. Skeleton density (SD) value, Vessel density (VD) value, Fractal dimension (FD) value, Vessel diameter index (VDI) value, Foveal Avascular Zone (FAZ) value are analyzed. Results: The total of 39 participants are included in this study. The SD value in the experimental group was significantly lower than that in control group [0.175 (0.166, 0.181) vs. 0.184 (0.175, 0.188), p=0.017]. Similarly, the VD value in the experimental group was significantly lower than that in the control group [0.333 (0.320, 0.350) vs. 0.354 (0.337, 0.364), p=0.024]. Additionally, the FD value in the experimental group was significantly lower than that in the control group [2.088 (2.083, 2.094) vs. 2.096 (2.090, 2.101), p=0.022]. As for the VDI and FAZ, VDI and FAZ values in the experimental group were lower than those in the control group, there was no significant difference in VDI and FAZ values between the two groups. Conclusions: Our study, using non-invasive and rapid OCTA imaging, confirmed decreased retinal vascular parameters and density in patients with moyamoya disease.