前列腺癌
新陈代谢
癌症
癌症研究
前列腺
生物
脂肪酸代谢
内分泌学
内科学
医学
作者
Raj K. Shrestha,Zeyad D. Nassar,Adrienne R. Hanson,Richard Iggo,Scott L. Townley,Jonas Dehairs,Chui Y. Mah,Madison Helm,Mohammadreza Alizadeh‐Ghodsi,Marie Pickering,Bart Ghesquière,Matthew J. Watt,Lake‐Ee Quek,Andrew J. Hoy,Wayne D. Tilley,Johannes V. Swinnen,Lisa M. Butler,Luke A. Selth
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2024-04-24
卷期号:84 (14): 2313-2332
被引量:2
标识
DOI:10.1158/0008-5472.can-23-1489
摘要
Solid tumors are highly reliant on lipids for energy, growth, and survival. In prostate cancer, the activity of the androgen receptor (AR) is associated with reprogramming of lipid metabolic processes. Here, we identified acyl-CoA synthetase medium chain family members 1 and 3 (ACSM1 and ACSM3) as AR-regulated mediators of prostate cancer metabolism and growth. ACSM1 and ACSM3 were upregulated in prostate tumors compared with nonmalignant tissues and other cancer types. Both enzymes enhanced proliferation and protected prostate cancer cells from death in vitro, whereas silencing ACSM3 led to reduced tumor growth in an orthotopic xenograft model. ACSM1 and ACSM3 were major regulators of the prostate cancer lipidome and enhanced energy production via fatty acid oxidation. Metabolic dysregulation caused by loss of ACSM1/3 led to mitochondrial oxidative stress, lipid peroxidation, and cell death by ferroptosis. Conversely, elevated ACSM1/3 activity enabled prostate cancer cells to survive toxic levels of medium chain fatty acids and promoted resistance to ferroptosis-inducing drugs and AR antagonists. Collectively, this study reveals a tumor-promoting function of medium chain acyl-CoA synthetases and positions ACSM1 and ACSM3 as key players in prostate cancer progression and therapy resistance. Significance: Androgen receptor-induced ACSM1 and ACSM3 mediate a metabolic pathway in prostate cancer that enables the utilization of medium chain fatty acids for energy production, blocks ferroptosis, and drives resistance to clinically approved antiandrogens.
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