A Rare Case of Severe Colitis Associated With a Pancreatic Neuroendocrine Tumor

Question: A 67-year-old man was admitted to the hospital because of a 1-month history of abdominal pain and diarrhea occurring 30 times per day. He had been undergoing treatment with the somatostatin analog lanreotide (120 mg subcutaneously every 4 weeks) for a nonfunctional pancreatic neuroendocrine tumor (NET-G3) (Figure A, arrow) with multiple liver metastases (Figure A, arrowhead) for 4 months. He also had comorbidities that included diabetes, which was being managed with insulin and metformin, and bronchial asthma requiring inhaler use.