Poor collateral flow with severe hypoperfusion explains worse outcome in acute stroke patients with atrial fibrillation

医学 心房颤动 改良兰金量表 内科学 心脏病学 优势比 冲程(发动机) 置信区间 灌注 侧支循环 缺血性中风 缺血 机械工程 工程类
作者
Jianhong Yang,Yuefei Wu,Xiang Gao,Qing Shang,Yao Xu,Qing Han,Jichuan Li,Chushuang Chen,Andrew Bivard,Mark Parsons,Longting Lin
出处
期刊:International Journal of Stroke [SAGE Publishing]
卷期号:18 (6): 689-696 被引量:7
标识
DOI:10.1177/17474930221138707
摘要

Atrial fibrillation (AF) is associated with poorer functional outcomes in acute stroke patients. It has been hypothesized that this is due to poor collateral recruitment.This study aimed to investigate the relationship between AF and collaterals with outcome in thrombectomy patients.This retrospective cohort study identified 1036 acute ischemic patients from the INternational Stroke Perfusion Imaging REgistry. The cohort was divided into two groups: 432 with AF and 604 without AF. Patients were stratified by collateral grades as good, moderate, and poor. Within each collateral grade, the prediction of AF versus No AF for good outcome (3-month modified Rankin Scale of 0-2) was determined. Then, within each collateral grade, perfusion was compared between those with and without AF.AF was negatively associated with good outcome in patients with poor collaterals (26.7% vs 51.2% for AF vs No AF, odds ratio = 0.32 (95% confidence interval = 0.22-0.50), p < 0.001), but not in patients with good (50.9% vs 58.1% for AF vs No AF, odds ratio = 0.75 (0.46-1.23), p = 0.249) or moderate collaterals (43.6% vs 50.9% for AF vs No AF, odds ratio = 0.75 (0.47-1.18), p = 0.214). AF was associated with severe hypoperfusion only in patients with poor collateral flow (54.0 vs 35.5 mL for AF vs No AF, p < 0.001).AF-related stroke is associated with more severe hypoperfusion and worse outcome in those with poor collaterals.
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