生物相容性材料
化学工程
羟丙基纤维素
材料科学
抗菌剂
共晶体系
纤维素
高分子化学
有机化学
化学
复合材料
聚合物
微观结构
生物医学工程
医学
工程类
作者
Daniela Filip,Doina Macocinschi,Mihaela Bălan,Cristian–Dragos Varganici,Raluca Petronela Dumitriu,Dragos Peptanariu,Cristina Tuchiluş,Mirela‐Fernanda Zaltariov
出处
期刊:Gels
[MDPI AG]
日期:2022-10-17
卷期号:8 (10): 666-666
被引量:6
摘要
Natural deep eutectic solvents (NADES)-hydroxypropyl cellulose (HPC) self-assembled gels with potential for pharmaceutical applications are prepared. FT-IR, 1HNMR, DSC, TGA and rheology measurements revealed that hydrogen bond acceptor–hydrogen bond donor interactions, concentration of NADES and the water content influence significantly the physico-chemical characteristics of the studied gel systems. HPC-NADES gel compositions have thermal stabilities lower than HPC and higher than NADES components. Thermal transitions reveal multiple glass transitions characteristic of phase separated systems. Flow curves evidence shear thinning (pseudoplastic) behavior. The flow curve shear stress vs. shear rate were assessed by applying Bingham, Herschel–Bulkley, Vocadlo and Casson rheological models. The proposed correlations are in good agreement with experimental data. The studied gels evidence thermothickening behavior due to characteristic LCST (lower critical solution temperature) behavior of HPC in aqueous systems and a good biocompatibility with normal cells (human gingival fibroblasts). The order of antibacterial and antifungal activities (S.aureus, E.coli, P. aeruginosa and C. albicans) is as follows: citric acid >lactic acid > urea > glycerol, revealing the higher antibacterial and antifungal activities of acids.
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