前列腺癌
雄激素
雄激素受体
医学
前列腺
内科学
内分泌学
癌症
癌症研究
肿瘤科
激素
作者
Haozhe Zhang,Zhou Yi,Zengzhen Xing,Rajiv Kumar Sah,Junru Hu,Hailiang Hu
标识
DOI:10.3390/ijms232113521
摘要
All aspects of prostate cancer evolution are closely related to androgen levels and the status of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways and AR, from castration-sensitive prostate cancer (CSPC) to castration-resistant prostate cancer (CRPC). Alterations in androgen metabolism and its response are one of the main reasons for prostate cancer drug resistance. In this review, we will introduce androgen metabolism, including how the androgen was synthesized, consumed, and responded to in healthy people and prostate cancer patients, and discuss how these alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
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