A Pilot Study of68Ga-PSMA11 and68Ga-RM2 PET/MRI for Evaluation of Prostate Cancer Response to High-Intensity Focused Ultrasound Therapy

医学 前列腺癌 高强度聚焦超声 核医学 前列腺 活检 磁共振成像 前列腺切除术 癌症 超声波 放射科 内科学
作者
Heying Duan,Pejman Ghanouni,Bruce L. Daniel,Jarrett Rosenberg,Guido Davidzon,Carina Marí Aparici,Christian A. Kunder,Geoffrey A. Sonn,Andrei Iagaru
出处
期刊:The Journal of Nuclear Medicine [Society of Nuclear Medicine and Molecular Imaging]
卷期号:64 (4): 592-597 被引量:16
标识
DOI:10.2967/jnumed.122.264783
摘要

Focal therapy for localized prostate cancer (PC) using high-intensity focused ultrasound (HIFU) is gaining in popularity as it is noninvasive and associated with fewer side effects than standard whole-gland treatments. However, better methods to evaluate response to HIFU ablation are an unmet need. Prostate-specific membrane antigen (PSMA) and gastrin-releasing peptide receptors are both overexpressed in PC. In this study, we evaluated a novel approach of using both 68Ga-RM2 and 68Ga-PSMA11 PET/MRI in each patient before and after HIFU to assess the accuracy of target tumor localization and response to treatment. Methods: Fourteen men, 64.5 ± 8.0 y old (range, 48–78 y), with newly diagnosed PC were prospectively enrolled. Before HIFU, the patients underwent prostate biopsy, multiparametric MRI, 68Ga-PSMA11, and 68Ga-RM2 PET/MRI. Response to treatment was assessed at a minimum of 6 mo after HIFU with prostate biopsy (n = 13), as well as 68Ga-PSMA11 and 68Ga-RM2 PET/MRI (n = 14). The SUVmax and SUVpeak of known or suspected PC lesions were collected. Results: Pre-HIFU biopsy revealed 18 cancers, of which 14 were clinically significant (Gleason score ≥ 3 + 4). Multiparametric MRI identified 18 lesions; 14 of them were at least score 4 in the Prostate Imaging–Reporting and Data System. 68Ga-PSMA11 and 68Ga-RM2 PET/MRI each showed 23 positive intraprostatic lesions; 21 were congruent in 13 patients, and 5 were incongruent in 5 patients. Before HIFU, 68Ga-PSMA11 identified all target tumors, whereas 68Ga-RM2 PET/MRI missed 2 tumors. After HIFU, 68Ga-RM2 and 68Ga-PSMA11 PET/MRI both identified clinically significant residual disease in 1 patient. Three significant ipsilateral recurrent lesions were identified, whereas 1 was missed by 68Ga-PSMA11. The pretreatment level of prostate-specific antigen decreased significantly after HIFU, by 66%. Concordantly, the pretreatment SUVmax decreased significantly after HIFU for 68Ga-PSMA11 (P = 0.001) and 68Ga-RM2 (P = 0.005). Conclusion: This pilot study showed that 68Ga-PSMA11 and 68Ga-RM2 PET/MRI identified the target tumor for HIFU in 100% and 86% of cases, respectively, and accurately verified response to treatment. PET may be a useful tool in the guidance and monitoring of treatment success in patients receiving focal therapy for PC. These preliminary findings warrant larger studies for validation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
fawr完成签到 ,获得积分10
2秒前
SYLH应助一诺相许采纳,获得10
4秒前
4秒前
小巧谷波完成签到 ,获得积分10
5秒前
忧郁紫翠完成签到,获得积分10
5秒前
able完成签到,获得积分10
6秒前
兔子发布了新的文献求助10
9秒前
青青完成签到 ,获得积分10
11秒前
kangshuai完成签到,获得积分10
12秒前
汤圆完成签到 ,获得积分10
13秒前
强公子关注了科研通微信公众号
13秒前
量子星尘发布了新的文献求助10
14秒前
qxz完成签到,获得积分10
15秒前
清秀的仙人掌完成签到,获得积分10
17秒前
RayLam完成签到,获得积分10
17秒前
18秒前
以韓完成签到 ,获得积分10
18秒前
imica完成签到 ,获得积分10
19秒前
Diamond完成签到 ,获得积分10
19秒前
可耐的问柳完成签到 ,获得积分10
20秒前
HH关注了科研通微信公众号
22秒前
兔子完成签到,获得积分10
22秒前
22秒前
xxx完成签到 ,获得积分10
24秒前
ash发布了新的文献求助10
25秒前
科研通AI5应助哭泣笑柳采纳,获得10
25秒前
倾听阳光完成签到 ,获得积分10
26秒前
iPhone7跑GWAS完成签到,获得积分10
26秒前
chinbaor完成签到,获得积分10
28秒前
怡然猎豹完成签到,获得积分10
29秒前
songvv发布了新的文献求助10
29秒前
ash完成签到,获得积分10
29秒前
33秒前
shezhinicheng完成签到,获得积分10
33秒前
桃花不用开了完成签到 ,获得积分10
34秒前
futong发布了新的文献求助10
36秒前
张瑞雪完成签到 ,获得积分10
39秒前
666完成签到,获得积分10
40秒前
大模型应助大橙子采纳,获得10
40秒前
maclogos发布了新的文献求助10
41秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022