乙酰化
顺铂
线粒体
急性肾损伤
肾
细胞
癌症研究
化学
药理学
医学
细胞生物学
生物化学
内科学
生物
化疗
基因
作者
Nannan Liang,Yue-Yue Guo,Xiaoyi Zhang,Ya-Hui Ren,Yi-Zhang He,Zhibing Liu,De‐Xiang Xu,Shen Xu
出处
期刊:PubMed
日期:2024-09-20
卷期号:: e2404753-e2404753
标识
DOI:10.1002/advs.202404753
摘要
Several studies have observed renal cell ferroptosis during cisplatin-induced acute kidney injury (AKI). However, the mechanism is not completely clear. In this study, oxidized arachidonic acid (AA) metabolites are increased in cisplatin-treated HK-2 cells. Targeted metabolomics showed that the end product of pyrimidine biosynthesis is decreased and the initiating substrate of pyrimidine biosynthesis is increased in cisplatin-treated mouse kidneys. Mitochondrial DHODH, a key enzyme for pyrimidine synthesis, and its downstream product CoQH
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