化学
正电子发射断层摄影术
丝氨酸
脑正电子发射断层扫描术
激酶
苏氨酸
Pet成像
临床前影像学
磷酸化
生物化学
神经科学
体内
生物
生物技术
作者
Wanqing Li,Xiaojun Zhang,Jie Ma,Jingyin Zhou,Xuan Di,Donglan Huang,Kaixiang Zhou,Jinming Zhang,Lu Wang,Hualong Fu,Mengchao Cui
标识
DOI：10.1021/acs.jmedchem.4c01263
摘要
Receptor-interacting serine/threonine protein kinase 1 (RIPK1) has emerged as an important regulator of pathologic cell death and inflammation and is implicated in the pathologies of various central nervous system diseases. In this study, we reported the development of three potent dihydropyrazole-cored RIPK1 positron emission tomography (PET) ligands [
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