Analysis of the recombination and evolution of the new type mutant pseudorabies virus XJ5 in China

伪狂犬病 生物 GenBank公司 遗传学 基因组 病毒 病毒学 毒力 重组 遗传分析 同源(生物学) 基因
作者
Luyao Jiang,Jinlong Cheng,Hao Pan,Jing Wang,Xinran Zhu,Jillian Wu,Haochun Pan,Ping Zhang,Jinzhu Zhou,Qingqing Gao,Changchao Huan,Song Gao
出处
期刊:BMC Genomics [Springer Nature]
卷期号:25 (1)
标识
DOI:10.1186/s12864-024-10664-w
摘要

Pseudorabies have caused enormous economic losses in China's pig industry and have recurred on many large pig farms since late 2011. The disease is caused by highly pathogenic, antigenic variant pseudorabies virus (vPRV) strains. Our laboratory isolated a pseudorabies virus in 2015 and named it XJ5. The pathogenic ability of this mutant strain was much stronger than that of the original isolate. After we sequenced its whole genome (GenBank accession number: OP512542), we found that its overall structure was not greatly changed compared with that of the previous strain Ea (KX423960.1). The whole genome alignment showed that XJ5 had a strong genetic relationship with the strains isolated in China after 2012 reported in GenBank. Based on the isolation time of XJ5 and the mutation and recombination analysis of programs, we found that the whole genome homology of XJ5 and other strains with Chinese isolates was greater than 95%, while the homology with strains outside Asia was less than 94%, which indicated that there may be some recombination and mutation patterns. We found that virulent PRV isolates emerged successively in China in 2011 and formed two different evolutionary clades from foreign isolates. At the same time, this may be due to improper immunization and the presence of wild strains in the field, and recent reports have confirmed that Bartha vaccine strains recombine with wild strains to obtain new pathogenic strains. We performed genetic evolution analysis of XJ5 isolated and sequenced in our laboratory to trace its possible mutations and recombination. We found that XJ5 may be the result of natural mutation of a virus in a branch of mutant strains widely existing in China.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
szk完成签到,获得积分10
刚刚
1秒前
开心元霜完成签到,获得积分10
1秒前
李健应助小墨墨采纳,获得10
1秒前
1秒前
Orange应助Sally采纳,获得10
2秒前
2秒前
田様应助夏宇采纳,获得10
4秒前
shanshan完成签到,获得积分20
4秒前
余三浪完成签到,获得积分10
4秒前
打打应助RRRRRRR采纳,获得200
4秒前
4秒前
liwenqiang发布了新的文献求助10
4秒前
甜瓜不熟完成签到,获得积分10
4秒前
喻萃发布了新的文献求助10
5秒前
森ok发布了新的文献求助10
5秒前
5秒前
5秒前
长生发布了新的文献求助10
6秒前
xiaotianli完成签到,获得积分10
7秒前
甜瓜不熟发布了新的文献求助10
7秒前
赘婿应助MS903采纳,获得10
8秒前
幕雪完成签到,获得积分0
8秒前
Ava应助努力追赶的科研人采纳,获得30
10秒前
Anonymous发布了新的文献求助10
10秒前
zhouyunan关注了科研通微信公众号
10秒前
球球完成签到,获得积分10
10秒前
FashionBoy应助liwenqiang采纳,获得10
11秒前
895_应助书生书真生采纳,获得10
11秒前
谜记完成签到 ,获得积分10
12秒前
12秒前
等待安柏发布了新的文献求助10
14秒前
mhl11应助科研通管家采纳,获得10
14秒前
乐乐应助科研通管家采纳,获得10
14秒前
慕青应助科研通管家采纳,获得10
14秒前
yanhebeilu应助科研通管家采纳,获得10
15秒前
tuanheqi应助科研通管家采纳,获得150
15秒前
自信的完成签到,获得积分10
15秒前
彭于晏应助科研通管家采纳,获得10
15秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Effect of reactor temperature on FCC yield 2000
Near Infrared Spectra of Origin-defined and Real-world Textiles (NIR-SORT): A spectroscopic and materials characterization dataset for known provenance and post-consumer fabrics 610
Promoting women's entrepreneurship in developing countries: the case of the world's largest women-owned community-based enterprise 500
Shining Light on the Dark Side of Personality 400
Introduction to Spectroscopic Ellipsometry of Thin Film Materials Instrumentation, Data Analysis, and Applications 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3308114
求助须知:如何正确求助?哪些是违规求助? 2941617
关于积分的说明 8504720
捐赠科研通 2616297
什么是DOI,文献DOI怎么找? 1429556
科研通“疑难数据库(出版商)”最低求助积分说明 663807
邀请新用户注册赠送积分活动 648748